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1994-10-25
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Document 3094
DOCN M94A3094
TI CD4 lymphocyte depletion: correlation with P24 antigen, neopterin, beta
2 microglobulin, CD8 count.
DT 9412
AU Salvato P; Thompson C; Houston Immunological Institute, Texas.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):155 (abstract no. PB0047). Unique
Identifier : AIDSLINE ICA10/94369481
AB OBJECTIVE: To describe laboratory markers as related to CD4 cell decline
in HIV disease progression. METHODS: 114 HIV+ pts. underwent lab.
testing for CD4 count, P24 antigen, neopterin, beta 2 microglobulin and
CD8 count. A chart review was conducted to determine length of known
exposure based upon high-risk sexual activity, date of blood/blood
product transfusion, known needle stick, or needle sharing, and
HIV-negative testing prior to actual seroconversion. RESULTS: (17 pts.
excluded: length of exposure not accurately determined). TABULAR DATA,
SEE ABSTRACT VOLUME. CONCLUSIONS: CD4 lymphocyte depletion is the
hallmark of HIV disease progression. Changes in other lab. markers also
appear predictable over time. Loss of CD4 cells results in increased CD8
cells until late in disease. Neopterin levels increase earlier in the
disease process than beta 2 microglobulin, although both increase with
disease progression. Early in disease P24 can be detected; P24 activity
tends to increase with disease progression. Combinations of these lab.
markers can enhance testing confidence and may facilitate patient
counseling, treatment modifications, and selection of study end points.
DE beta 2-Microglobulin/ANALYSIS Biological Markers/BLOOD
Biopterin/*ANALOGS & DERIVATIVES/BLOOD Blood Transfusion *CD4-CD8
Ratio Human HIV Core Protein p24/*BLOOD HIV
Infections/BLOOD/IMMUNOLOGY/*PHYSIOPATHOLOGY HIV
Seropositivity/BLOOD/IMMUNOLOGY/*PHYSIOPATHOLOGY Needle Sharing
Needlestick Injuries Predictive Value of Tests Sex Behavior Time
Factors T4 Lymphocytes/*IMMUNOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).